Novel Targeted Pet Nanoparticles for Diagnosis of Thrombosis, Inflammation and Prevention of Myocardial Infection.

Boronate-Phenolic Network Capsules with Dual Response to Acidic pH and cis-Diols

J Guo, H Sun, K Alt, BL Tardy, JJ Richardson, T Suma, H Ejima, J Cui, CE Hagemeyer, F Caruso

2015-08-01

Dual-responsive boronate-phenolic network (BPN) capsules are fabricated by the complexation of phenylborate and phenolic materials..

A Versatile Approach for the Site‐Specific Modification of Recombinant Antibodies Using a Combination of Enzyme‐Mediated Bioconjugation and Click Chemistry

Karen Alt, Brett M Paterson, Erik Westein, Stacey E Rudd, Stan S Poniger, Shweta Jagdale, Katie Ardipradja, Timothy U Connell, Guy Y Krippner, Ashish KN Nair, Xiaowei Wang, Henri J Tochon‐Danguy, Paul S Donnelly, Karlheinz Peter, Christoph E Hagemeyer

2015-06-22

<jats:title>Abstract</jats:title><jats:p>A unique two‐step modular system for site‐specific antibody modification and conjugation ..

A versatile approach for the site-specific modification of recombinant antibodies using a combination of enzyme-mediated bioconjugation and click chemistry

K Alt, BM Paterson, E Westein, SE Rudd, SS Poniger, S Jagdale, K Ardipradja, TU Connell, GY Krippner, AKN Nair, X Wang, HJ Tochon-Danguy, PS Donnelly, K Peter, CE Hagemeyer

2015-06-01

A unique two-step modular system for site-specific antibody modification and conjugation is reported. The first step of this appro..

Engineering poly(ethylene glycol) particles for improved biodistribution

J Cui, R De Rose, K Alt, S Alcantara, BM Paterson, K Liang, M Hu, JJ Richardson, Y Yan, CM Jeffery, RI Price, K Peter, CE Hagemeyer, PS Donnelly, SJ Kent, F Caruso

2015-02-24

We report the engineering of poly(ethylene glycol) (PEG) hydrogel particles using a mesoporous silica (MS) templating method via t..

Single-Chain antibody conjugated to a cage amine chelator and labeled with positron-emitting copper-64 for diagnostic imaging of activated platelets

K Alt, BM Paterson, K Ardipradja, C Schieber, G Buncic, B Lim, SS Poniger, B Jakoby, X Wang, GJ Okeefe, HJ Tochon-Danguy, AM Scott, U Ackermann, K Peter, PS Donnelly, CE Hagemeyer

2014-08-04

Imaging of activated platelets using an activation specific anti-GPIIb/IIIa integrin single-chain antibody (scFv<inf>anti-LIBS</in..

Engineering multifunctional capsules through the assembly of metal-phenolic networks

J Guo, Y Ping, H Ejima, K Alt, M Meissner, JJ Richardson, Y Yan, K Peter, D Von Elverfeldt, CE Hagemeyer, F Caruso

2014-05-26

Metal-organic coordination materials are of widespread interest because of the coupled benefits of inorganic and organic building ..

Detection of activated platelets in a mouse model of carotid artery thrombosis with 18F-labeled single-chain antibodies

K Ardipradja, SD Yeoh, K Alt, G O'Keefe, A Rigopoulos, DW Howells, AM Scott, K Peter, U Ackerman, CE Hagemeyer

2014-03-01

Introduction: Activated platelets are key players in thrombosis and inflammation. We previously generated single-chain antibodies ..

Fully automated synthesis and coupling of [18F]FBEM to glutathione using the iPHASE FlexLab module

U Ackermann, L Plougastel, C Wichmann, YW Goh, SD Yeoh, SS Poniger, HJ Tochon-Danguy, AM Scott

2014-01-01

Site-specific radiolabelling of peptides or antibodies using [ ¹⁸F]FBEM is often preferred over non-site-specific radio..

Improved synthesis of [18F]FLETT via a fully automated vacuum distillation method for [18F]2-fluoroethyl azide purification

U Ackermann, L Plougastel, YW Goh, SD Yeoh, AM Scott

2014-01-01

The synthesis of [¹⁸F]2-fluoroethyl azide and its subsequent click reaction with 5-ethynyl-2'-deoxyuridine (EDU) to for..